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ChemInform Abstract: Modular Amino Acids and β-Amino Alcohol-Based Chiral Ligands for Enantioselective Addition of Diethylzinc to Aromatic Aldehydes.

✍ Scribed by Shaohua Gou; Zhongbin Ye; Guangjun Gou; Mingming Feng; Jing Chang

Publisher
John Wiley and Sons
Year
2011
Weight
29 KB
Volume
42
Category
Article
ISSN
0931-7597

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📜 SIMILAR VOLUMES

Modular amino acid amide chiral ligands
Modular amino acid amide chiral ligands for enantioselective addition of diethylzinc to aromatic aldehydes
✍ Shaohua Gou; Zhongbin Ye; Jing Chang; Guangjun Gou; Mingming Feng 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

## Abstract Enantioselective addition of diethylzinc to a series of aromatic aldehydes was developed using a modular amino acid amide chiral ligand (2__S__)‐3‐phenyl‐__N__‐((__R__)‐1‐phenyl‐ethyl)‐2‐(tosylamino)propanamide without using titanium complex. The catalytic system employing 10 mol% of 1g

Modular amino acids-based chiral ligands
Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones
✍ Shaohua Gou; Zaher M. A. Judeh 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 1 views

## Abstract New amino acid‐based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et~2~Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high __ee__ of up to 72% were obtained using ligand (__S__)‐**1e** u