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ChemInform Abstract: Modular Amino Acid Amide Chiral Ligands for Enantioselective Addition of Diethylzinc to Aromatic Aldehydes.

✍ Scribed by Shaohua Gou; Zhongbin Ye; Jing Chang; Guangjun Gou; Mingming Feng

Publisher
John Wiley and Sons
Year
2011
Weight
36 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

Among 9 ligands tested, the derivative AAA is found to be the most efficient one and the e.e.

πŸ“œ SIMILAR VOLUMES

Modular amino acid amide chiral ligands
Modular amino acid amide chiral ligands for enantioselective addition of diethylzinc to aromatic aldehydes
✍ Shaohua Gou; Zhongbin Ye; Jing Chang; Guangjun Gou; Mingming Feng πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 2 views

## Abstract Enantioselective addition of diethylzinc to a series of aromatic aldehydes was developed using a modular amino acid amide chiral ligand (2__S__)‐3‐phenyl‐__N__‐((__R__)‐1‐phenyl‐ethyl)‐2‐(tosylamino)propanamide without using titanium complex. The catalytic system employing 10 mol% of 1g

Modular amino acids-based chiral ligands
Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones
✍ Shaohua Gou; Zaher M. A. Judeh πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 131 KB πŸ‘ 1 views

## Abstract New amino acid‐based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et~2~Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high __ee__ of up to 72% were obtained using ligand (__S__)‐**1e** u