Biphenol-Based Phosphoramidite Ligands for the Enantioselective Copper-Catalyzed Conjugate Addition of Diethylzinc.
โ Scribed by Alexandre Alexakis; Damien Polet; Stephane Rosset; Sebastien March
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 42 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract New amino acidโbased modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et~2~Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high __ee__ of up to 72% were obtained using ligand (__S__)โ**1e** u