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Modified nucleotide polymers as inhibitors of DNA polymerases

✍ Scribed by B.I.Sahai Srivastava


Book ID
115746046
Publisher
Elsevier Science
Year
1975
Weight
358 KB
Volume
414
Category
Article
ISSN
0005-2787

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Synthetically modified DNAs as substrate
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DNA polymerase enzymes process their natural substrates with very high specificity. Yet recent experiments have shown that these enzymes can also process DNA in which the backbone or bases are modified to a surprising degree. Such experiments have important implications in understanding the mechanis