𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Models for MHC-restricted T-cell antigen recognition

✍ Scribed by Michael A. Norcross

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
671 KB
Volume
5
Category
Article
ISSN
0265-9247

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✦ Synopsis

Current models for T-cell recognition of foreign antigen depict the T-cell receptor as having a single antibody-like combining site which bindr a complex of MHC and antigen. An alternative hypothesis is presented here; it is proposed that the first domains of the MHC function as inverted V-like regions to complement the TcR V-regions in creating antigen binding sites.

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Single T cell probes for antigen/MHC expression
✍ Nilabh Shastri πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 473 KB

T-cell receptor binding to the antigen/MHC ligand on the surface of antigen-presenting cells is the central event in T-cell activation. Methods have been developed for measuring this recognition event in single T cells and have allowed their use as 'probes' for antigen/MHC expression. Single cell as