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Modeling the dynamics of a mutated stem-loop in the SL1 domain of HIV-1Lai genomic RNA by 1H-NOESY spectra

✍ Scribed by Simone Fausti; Giovanni La Penna; Jacques Paoletti; Daniel Genest; Gérard Lancelot; Angelo Perico

Book ID: 110299007
Publisher: Springer Netherlands
Year: 2001
Tongue: English
Weight: 219 KB
Volume: 20
Category: Article
ISSN: 0925-2738
DOI: 10.1023/a:1011251308365

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Insight into the intrinsic flexibility of the SL1 stem-loop from genomic RNA of HIV-1 as probed by molecular dynamics simulation

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## Abstract The SL1 stem‐loop is the dimerization initiation site for linking the two copies of the RNA forming the HIV‐1 genome. The 26 nucleotides stem contains a defect consisting on a highly conserved G‐rich 1‐3 asymmetrical internal loop, which is a major site for nucleocapsid protein binding.

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Conformational Pathway for the Kissing Complex→Extended Dimer Transition of the SL1 Stem-Loop from Genomic HIV-1 RNA as Monitored by Targeted Molecular Dynamics Techniques

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HIV-1 Genome Dimerization: Formation Kinetics and Thermal Stability of Dimeric HIV-1 Lai RNAs Are Not Improved by the 1−232 and 296−790 Regions Flanking the Kissing-Loop Domain †

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On the stability of different experimental dimeric structures of the SL1 sequence from the genomic RNA of HIV-1 in solution: A molecular dynamics simulation and electrophoresis study

✍ S. Aci; L. Gangneux; J. Paoletti; D. Genest 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 400 KB 👁 2 views

## Abstract SL1 is a stem–loop RNA sequence from the genome of HIV‐1 thought to be the initiation site for the dimerization of the retroviral genomic RNA. The aim of this study is to check the stability in solution of different experimental dimeric structures available in the literature. Two kinds