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Base Pairing at the Stem-loop Junction in the SL1 Kissing Complex of HIV-1 RNA: A Thermodynamic Study Probed by Molecular Dynamics Simulation

✍ Scribed by Aci, Samia; Ramstein, Jean; Genest, Daniel

Book ID
127345718
Publisher
Adenine Press
Year
2004
Tongue
English
Weight
449 KB
Volume
21
Category
Article
ISSN
0739-1102

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Insight into the intrinsic flexibility of the SL1 stem-loop from genomic RNA of HIV-1 as probed by molecular dynamics simulation
✍ Sonia Mazier; Daniel Genest 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 319 KB

## Abstract The SL1 stem‐loop is the dimerization initiation site for linking the two copies of the RNA forming the HIV‐1 genome. The 26 nucleotides stem contains a defect consisting on a highly conserved G‐rich 1‐3 asymmetrical internal loop, which is a major site for nucleocapsid protein binding.