Conformational Pathway for the Kissing Complex→Extended Dimer Transition of the SL1 Stem-Loop from Genomic HIV-1 RNA as Monitored by Targeted Molecular Dynamics Techniques

Insight into the intrinsic flexibility o

Insight into the intrinsic flexibility of the SL1 stem-loop from genomic RNA of HIV-1 as probed by molecular dynamics simulation

✍ Sonia Mazier; Daniel Genest 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 319 KB

## Abstract The SL1 stem‐loop is the dimerization initiation site for linking the two copies of the RNA forming the HIV‐1 genome. The 26 nucleotides stem contains a defect consisting on a highly conserved G‐rich 1‐3 asymmetrical internal loop, which is a major site for nucleocapsid protein binding.