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MLL amplification in acute myeloid leukemia

✍ Scribed by Juan C. Pajuelo-Gámez; José Cervera; Zaida García-Casado; Armando V. Mena-Durán; Ana Valencia; Eva Barragán; Esperanza Such; Pascual Bolufer; Miguel A. Sanz

Book ID
113513086
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
560 KB
Volume
174
Category
Article
ISSN
0165-4608

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Amplification of the MLL gene on double
Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome
✍ Berthold Streubel; Peter Valent; Ulrich Jäger; Martin Edelhäuser; Hannes Wandt; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB 👁 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi