Expression of BEX1 in acute myeloid leukemia with MLL rearrangements
โ Scribed by Quentmeier, H; Tonelli, R; Geffers, R; Pession, A; Uphoff, C C; Drexler, H G
- Book ID
- 110056342
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 122 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0887-6924
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Three childhood acute monoblastic leukemias (AML M5) with granulocytic sarcomas (GSs) are described. All displayed 11q23/MLL abnormalities, t(9;11)(p22;q23) in two cases and t(11;17)(q23;q21) in one case, constituting around 20% of all 11q23-positive AML cytogenetically investigated in our departmen
## Abstract Rearrangements of __MLL__ are regarded as primary oncogenic events in acute leukemia. We report the case of a patient with acute myeloid leukemia with a complex abnormal karyotype at diagnosis who showed a putative stem line with monosomy 5 and a rearrangement of chromosome 17 as the on