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Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

โœ Scribed by Mullighan, C G; Kennedy, A; Zhou, X; Radtke, I; Phillips, L A; Shurtleff, S A; Downing, J R

Book ID
110058318
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
600 KB
Volume
21
Category
Article
ISSN
0887-6924

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Acute myeloid leukemia with a complex ab
Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile
โœ Claudia Schoch; Wolfgang Kern; Alexander Kohlmann; Wolfgang Hiddemann; Susanne S ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 583 KB

## Abstract Acute myeloid leukemia (AML) with a complex aberrant karyotype is a distinct biological entity. It is characterized by: (1) a sharp increase in incidence above age 50; (2) a characteristic pattern of chromosomal gain and, especially, loss, that is, of 5q14q33, 7q32q35, and 17p13, transl