Adult de novo acute myeloid leukemias with MLL rearrangements
✍ Scribed by Ma del Mar Bellido; Josep F. Nomdedéu
- Book ID
- 114119624
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 135 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0145-2126
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Three childhood acute monoblastic leukemias (AML M5) with granulocytic sarcomas (GSs) are described. All displayed 11q23/MLL abnormalities, t(9;11)(p22;q23) in two cases and t(11;17)(q23;q21) in one case, constituting around 20% of all 11q23-positive AML cytogenetically investigated in our departmen
## Abstract Rearrangements of __MLL__ are regarded as primary oncogenic events in acute leukemia. We report the case of a patient with acute myeloid leukemia with a complex abnormal karyotype at diagnosis who showed a putative stem line with monosomy 5 and a rearrangement of chromosome 17 as the on