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Mixed-Backbone Oligonucleotides Containing Segments of Deoxynucleosides Phosphorothioate and 2'- O -Methylribonucleosides Methylphosphonate: Synthesis and Properties

✍ Scribed by Guo, Maojun; Yu, Dong; Agrawal, Sudhir


Book ID
127261072
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
198 KB
Volume
144
Category
Article
ISSN
1042-6507

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Synthesis and structural and thermodynam
✍ Hiroyuki Tsuruoka; Koh-ichiroh Shohda; Takeshi Wada; Mitsuo Sekine πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 273 KB

Conformation of the sugar, backbone and glycosidic bond of synthetic 2'-O-phosphorylated diuridylate U(2'-p)pU 1 was studied by NMR and CD. It was found that the 5' upstream ribose has predominantly an S-type of conformation. Tridecadeoxyuridylates incorporating a 2'-O-phosphorylated uridine U(2'-p)