Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modiยฎed oligonucleotides showed similar binding properties and enhanced re
โฆ LIBER โฆ
Synthesis, biophysical properties, and stability studies of mixed backbone oligonucleotides containing segments of methylphosphotriester internucleotidic linkages
โ Scribed by Radhakrishnan P. Iyer; Dong Yu; Zhiwei Jiang; Sudhir Agrawal
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 943 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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Nuclewide dimers witb a Nsyanoguanidine linkage were syntbesked and used as building blocks for oligonwkotide synthesis. Oligonwkotides composed of alternating phosphod.iester and cyanoguaoidine functions are still able to hybridize with a complementary natural oligodeoxynucleotide.