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Synthesis, enzymatic stability and physicochemical properties of oligonucleotides containing a N-cyanoguanidine linkage.

โœ Scribed by C. Pannecouque; F. Vandendriessche; J. Rozenski; G. Janssen; R. Busson; A. Van Aerschot; P. Claes; P. Herdewijn

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
900 KB
Volume
50
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Nuclewide dimers witb a Nsyanoguanidine linkage were syntbesked and used as building blocks for oligonwkotide synthesis. Oligonwkotides composed of alternating phosphod.iester and cyanoguaoidine functions are still able to hybridize with a complementary natural oligodeoxynucleotide.

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