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Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages

✍ Scribed by Kanda S Ramasamy; Liyan He; Vesna Stoisavljevic; Brent Harpham; Wilfried Seifert

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 146 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00661-4

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✦ Synopsis

Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modi®ed oligonucleotides showed similar binding properties and enhanced resistance to exonucleases compared to natural oligonucleotides.

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