𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mitogenic proteins of the 3T3 plasma membrane

✍ Scribed by Michael A. Lieberman

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
476 KB
Volume
114
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

A mitogenic factor from 3T3 plasma membranes has been identified and partially characterized. The factor appears to be a peripheral membrane protein that can be released by mild trypsin, chymotrypsin, or plasmin treatment. This component is sensitive to heat and acid, and has a molecular weight in the range of 150,000-200,000 daltons as determined by gel filtration. A similar mitogenic activity has also been found on the membranes of both SV-40-transformed 3T3 cells and human fibroblasts. The factor appears to be distinct from all previously described mitogenic components.

πŸ“œ SIMILAR VOLUMES

Cholesterol levels and plasma membrane f
Cholesterol levels and plasma membrane fluidity in 3T3 and SV101-3T3 cells
✍ Scandella, Carl J. ;Hayward, James A. ;Lee, Nancy πŸ“‚ Article πŸ“… 1979 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 339 KB

Polyene antibiotics such as filipin selectively inhibit wheat germ agglutinin-induced agglutination of transformed and malignant cells compared to normal cells (Hatten ME, Burger MM: Biochemistry 18: 739, 1979). Since filipin binds specifically to cholesterol, we measured cholesterol levels in 3T3 c

Regulation of the metabolism of plasma m
Regulation of the metabolism of plasma membrane proteins in hepatocytes
✍ Darrell Doyle; Anh V. Le πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 406 KB

The protein composition of the plasma membrane of animal cells is complex. Cells of hepatocyte origin in tissue culture have, for example, at least 100 proteins and glycoproteins externally oriented on their plasma membrane (1, 2). The organization of these proteins in the plasma membrane of cells i

Mitogenic effects of murine serum and fi
Mitogenic effects of murine serum and fibroblast growth factor on EGF nonproliferative variants of 3T3
✍ Pruss, Rebecca M. ;Herschman, Harvey R. πŸ“‚ Article πŸ“… 1979 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 190 KB

## Abstract The enhanced ability of murine serum to support growth of 3T3 cells, when compared with fetal calf serum, is also evident on variants of 3T3 cells lacking the ability to bind epidermal growth factor (EGF). Variant 3T3 cell lines unable to bind EGF also retain a mitogenic response to fib