Stereoselective binding of zopiclone to
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Christine Fernandez; FranΓ§ois Gimenez; Alain Thuillier; Robert Farinotti
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Article
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1999
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John Wiley and Sons
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English
β 63 KB
The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and β£1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 Β± 5.5%, 83.8 Β± 5.2%, and 75