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Binding of chlorpheniramine enantiomers to human plasma proteins

✍ Scribed by Bui Tung Hiep; François Gimenez; Vu Khanh; Nguyen Kim Hung; Alain Thuillier; Robert Farinotti; Christine Fernandez

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
63 KB
Volume
11
Category
Article
ISSN
0899-0042

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✦ Synopsis

The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and ␣-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38% vs. 23%), to albumin (20% vs. 15%) and to ␣-glycoprotein acid (23% vs. 5%).

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