Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR)

Determination of drug–plasma protein bin

Determination of drug–plasma protein binding using human serum albumin chromatographic column and multiple linear regression model

✍ Francis Beaudry; Michel Coutu; Nigel K. Brown 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 1 views

Reversible attachment to serum proteins plays a significant role in pharmacokinetics and pharmacodynamics, and a clear understanding of this process is fundamental in the development of the rational use of many therapeutics agents. Over the last few years, it has been demonstrated that immobilized h