✦ LIBER ✦

Regulation of the metabolism of plasma membrane proteins in hepatocytes

✍ Scribed by Darrell Doyle; Anh V. Le

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 406 KB
Volume: 1
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840010216

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✦ Synopsis

The protein composition of the plasma membrane of animal cells is complex. Cells of hepatocyte origin in tissue culture have, for example, at least 100 proteins and glycoproteins externally oriented on their plasma membrane (1, 2). The organization of these proteins in the plasma membrane of cells in tissue culture is relatively simple compared to the organization of the plasma membrane in the hepatocyte in the liver. Cells in culture often lack polarity and regional specializations of the plasma membrane, i.e., tight and gap junctions, bile canaliculi, etc., that characterize the same cell in situ. Carbohydrate

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