Mitochondrial DNA Adducts in the Lung and Liver of F344 Rats Chronically Treated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and ( S )-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
β Scribed by Stepanov, Irina; Hecht, Stephen S.
- Book ID
- 127327915
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 541 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0893-228X
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## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di
The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c