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Formation of Formaldehyde Adducts in the Reactions of DNA and Deoxyribonucleosides with α-Acetates of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N -Nitrosodimethylamine (NDMA)

✍ Scribed by Cheng, Guang; Wang, Mingyao; Upadhyaya, Pramod; Villalta, Peter W.; Hecht, Stephen S.


Book ID
127357930
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
336 KB
Volume
21
Category
Article
ISSN
0893-228X

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## Abstract Urinary metabolites of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di