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MiR-15a and miR-16-1 cluster functions in human leukemia

✍ Scribed by Calin, G. A.; Cimmino, A.; Fabbri, M.; Ferracin, M.; Wojcik, S. E.; Shimizu, M.; Taccioli, C.; Zanesi, N.; Garzon, R.; Aqeilan, R. I.; Alder, H.; Volinia, S.; Rassenti, L.; Liu, X.; Liu, C.-g.; Kipps, T. J.; Negrini, M.; Croce, C. M.

Book ID
118013099
Publisher
National Academy of Sciences
Year
2008
Tongue
English
Weight
341 KB
Volume
105
Category
Article
ISSN
0027-8424

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## Abstract Micro RNAs (miRs) are small noncoding RNAs, functioning as antisense regulators of other RNAs. __miR‐15a__ and __miR‐16‐1__ genes are located at chromosome 13q14, a region which is frequently deleted in pituitary tumors. An inverse correlation has been shown in B cell chronic lymphocyti