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The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

✍ Scribed by Bonci, Désirée; Coppola, Valeria; Musumeci, Maria; Addario, Antonio; Giuffrida, Raffaella; Memeo, Lorenzo; D'Urso, Leonardo; Pagliuca, Alfredo; Biffoni, Mauro; Labbaye, Catherine

Book ID: 109926125
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 578 KB
Volume: 14
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm.1880

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## Abstract MicroRNAs (miRNAs) are small, non‐coding RNAs that negatively regulate the expression of protein coding genes. In this study, we screened highly informative prostate cancer cell lines and xenografts (__n__ = 42) for miRNA gene copy number and expression changes. The expression profiling