Minimal residual disease monitoring based on FLT3 internal tandem duplication in adult acute myeloid leukemia
✍ Scribed by Emna Abdelhamid; Claude Preudhomme; Nathalie Helevaut; Olivier Nibourel; Claude Gardin; Philippe Rousselot; Sylvie Castaigne; Bérengère Gruson; Céline Berthon; Zohra Soua; Aline Renneville
- Book ID
- 113773604
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 581 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0145-2126
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📜 SIMILAR VOLUMES
## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte
## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si