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Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia

✍ Scribed by Iwai, T; Yokota, S; Nakao, M; Okamoto, T; Taniwaki, M; Onodera, N; Watanabe, A; Kikuta, A; Tanaka, A; Asami, K

Book ID
110054045
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
194 KB
Volume
13
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte