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Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

✍ Scribed by Kiyoi, H; Naoe, T; Yokota, S; Nakao, M; Minami, S; Kuriyama, K; Takeshita, A; Saito, K; Hasegawa, S; Shimodaira, S

Book ID
110053604
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
294 KB
Volume
11
Category
Article
ISSN
0887-6924

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene