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Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

✍ Scribed by Rombouts, W J C; Blokland, I; Löwenberg, B; Ploemacher, R E

Book ID: 110054511
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 141 KB
Volume: 14
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401731

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene