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Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type

✍ Scribed by Weina Chen; Dan Jones; L. Jeffrey Medeiros; Rajyalashmi Luthra; Pei Lin

Book ID: 108673353
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 66 KB
Volume: 130
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2005.05666.x

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si