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FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

✍ Scribed by F. M. Abu-Duhier; A. C. Goodeve; G. A. Wilson; M. A. Gari; I. R. Peake; D. C. Rees; E. A. Vandenberghe; P. R. Winship; J. T. Reilly


Book ID
108672324
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
223 KB
Volume
111
Category
Article
ISSN
0007-1048

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte