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Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: a marker for the monitoring of minimal residual disease

โœ Scribed by Nakao, M; Janssen, J W G; Erz, D; Seriu, T; Bartram, C R

Book ID
110054476
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
88 KB
Volume
14
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene