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Microwave-assisted synthesis, molecular docking and antitubercular activity of 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives

✍ Scribed by Mohan, Sahoo Biswa; Ravi Kumar, B.V.V.; Dinda, S.C.; Naik, D.; Prabu Seenivasan, S.; Kumar, Vanaja; Rana, Dharmarajsinh N.; Brahmkshatriya, Pathik S.


Book ID
118052869
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
493 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract The synthesis of 6‐methylsulfanyl‐2,4‐dithioxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile **4** is described. Compound **4** was reacted with various alkylants. The reaction with chloroacetic acid derivatives results in the formation of thieno[2,3‐__d__]pyrimidines **8**. When methyl i