Forty-three sporadic gastric cancers were analyzed with regard to whether mutations of simple repeated sequences in the transforming growth factor fi type II receptor ( T p -I / ) gene are associated with microsatellite instability (MSI) and gastric carcinogenesis. In 12 ofthe 43 cancers (28%), MSI
✦ LIBER ✦
Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas
✍ Scribed by Shuichi Izumoto; Norio Arita; Takanori Ohnishi; Shoju Hiraga; Takuyu Taki; Naohiro Tomita; Masayuki Ohue; Toru Hayakawa
- Book ID
- 117468429
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 946 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0304-3835
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Alteration of transforming growth factor beta1 (TGF-beta1) type II receptor (RII) appears to cause unresponsiveness to TGF-beta1 in tumorigenic cells. Defect in the mononucleotide repeat sequence, i.e., poly A region of TGF-beta1RII gene has been reported to be related to replication error-positive