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Micromethod for the Determination of Heparin in Plasma after Intravenous and Subcutaneous Administration

✍ Scribed by P. Oreste; M. Peruzzi; P. Stella

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
445 KB
Volume
210
Category
Article
ISSN
0003-2697

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✦ Synopsis

A sensitive method has been developed for extracting and analyzing heparin from plasma after intravenous and subcutaneous administration in humans and rabbits. The glycosaminoglycans are precipitated from the biological fluid as cetylpyridinium salt, and heparin is cleaved with heparinase. The reaction products are analyzed by polyacrylamide gel electrophoresis and visualized by staining with Azure A/ammoniacal silver. With this method (12 \mathrm{ng}) of heparin can be detected. (C) 1983 Academic Press, Inc.

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