๐”– Bobbio Scriptorium
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Micromethod for determination of meperidine in plasma

โœ Scribed by M. A. Evans; R. D. Harbison

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
215 KB
Volume
66
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A GLC method utilizing a flame-ionization detector is described for the analysis of meperidine in blood plasma. Meperidine is extracted with ether from plasma that has been made basic with sodium hydroxide. The ether extract is evaporated to dryness, and the residue is dissolved in carbon disulfide for GLC analysis. An internal standard, N',N'-diethylaminoacetyl-2,6-xylidine, is used to quantitate meperidine. The extraction efficiency from plasma is 85%, and as little as 0.05 microng of meperidine can be quantitatively determined in 1 ml of plasma.

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