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Microdetermination of hyoscyamine and scopolamine in mixtures

✍ Scribed by Sawsan El-Masry; Saleh A. H. Khalil

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
293 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

Following the acid-dye technique, hyoscyamine (or atropine) could he selectively determined in the presence of scopolamine, using bromcresol purple at pH 6.6. Total alkaloids were determined using bromthymol blue at pH 5.6. By referring to calibration curves of the two alkaloids with the appropriate dye, the concentration of each alkaloid in the mixture could be computed. The suggested procedure was adopted to analyze the two alkaloids in synthetic mixtures. As low as 0.05 mg. of each alkaloid could be estimated, with average percentage recoveries of 98.6 and 101.5 for hyoscyamine and scopolamine, respectively. Tincture of belladonna was assayed following a modification of the suggested method. The results obtained were comparable with those obtained following the BP method.

Keyphrases 0 Hyoscyamine mixtures with scopolamine-acid-dye

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