The synthesis of the highly chemotactic leukotriene B3 (la) and of its 6-trans isomer l b by Witrig reaction of the chiral phosphonium salt 3 with the aldehyde 4 is described. A new synthetic route to 4 starting from D-arabinose is reported. ## Synthese voo Leukohien B, Die Synthese des stark che
Microbial hydroxylation of cyclohexylcyclohexane:Synthesis of an analogue of leukotriene-B3
β Scribed by H. Geoff Davies; Michael J. Dawson; Gordon C. Lawrence; John Mayall; David Noble; Stanley M. Roberts; Michael K. Turner; Wilfred F. Wall
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 202 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Cyclohexylcyclohexane was transformed into cyclohexylcyclohexanediols using selected fungi: 4,4'-cyclohexylcyclohexanediol was converted into an snalogue of leukotriene-
B3'
Oxygenases
π SIMILAR VOLUMES
3(S)-Hydmxy-m B, (la), its 3(R)-epima lb, and a 14.15acetylenic endogue were effWently prepad vie cheletiakamtrolled reduaion of keme 12. obtained by acetylide addition te ehbal Ehydmxylacmes 7p. Leukotriene B4 (LTB,) is an important lipid mediator in inflammatory and immunologic responses.r In rec