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Michael Addition of Hydroxylamines to Activated Double Bonds. A Convenient Synthesis of N,N-Dialkyl Hydroxylamines

✍ Scribed by Sayigh, A. A. R.; Ulrich, Henri; Green, M.


Book ID
120007535
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
267 KB
Volume
29
Category
Article
ISSN
0022-3263

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Diastereoselective addition of terminal
✍ Samir K. Patel; Sandrine Py; Shashi U. Pandya; Pierre Y. Chavant; Yannick VallΓ©e πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 521 KB

1,3-Asymmetric induction in the Et 2 Zn-catalyzed addition of terminal alkynes was studied with nitrones bearing a chiral auxiliary on their nitrogen atom. The obtained propargylic N-hydroxylamines were generally isolated in good yields and with satisfactory to excellent diastereoselectivities.