Methylthiomethyl, a new carboxyl protecting group in peptide synthesis
β Scribed by Dossena, Arnaldo ;Palla, Gerardo ;Marchelli, Rosangela ;Lodi, Tiziana
- Book ID
- 115098158
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 316 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0367-8377
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π SIMILAR VOLUMES
Acetol can be conveniently used as a reagent for the protection of carboxylic acids in peptide synthesis. It has been found to be inert and stable to hydrogenolytic and acidolytic conditions normally used in peptide synthesis. Deblocking has been selectively achieved under mild conditions using Bu4N
## Abstract The preparation and properties of thirty two N(Ξ±)β[2β(__p__βphenylazophenyl)βisopropylcarbonyl]βaminoβacids and derivatives are described. The new coloured protecting group (AZOCβ) can be easily and selectively removed with mild acid treatment, much the same as the 2β(biphenyl)βisopropy