A New Amino Protecting Group for Amino-acids in Peptide Synthesis
✍ Scribed by HALPERN, B.; JAMES, L. B.
- Book ID
- 109635537
- Publisher
- Nature Publishing Group
- Year
- 1964
- Tongue
- English
- Weight
- 207 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/202592a0
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📜 SIMILAR VOLUMES
## Abstract We have found a novel way of protecting the hydroxyl function in hydroxy‐L‐amino acids, making use of the t‐butoxy group, which is readily split by acids, but not by bases. This group is introduced by acid‐catalysed addition of isobutene to N‐acylated hydroxy‐L‐amino acids. The blockin
Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied. The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF. The formation of 3-benzyltyrosine from e-benzyl tyrosine in
## Abstract The value of several reagents capable of removing quantitatively the α‐amino protecting group of NPS‐aminoacyl‐ or peptidyl‐derivatives is assessed, by comparison with the reagents currently used, __i.e.__ hydrogen chloride, RS^–^‐nucleophiles or alkyl thioamides, especially with regard