𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Methylphosphinyl (Dmp): A new protecting group of tyrosine suitable for peptide synthesis by use of boc-amino acids

✍ Scribed by Masaaki Ueki; Yoshiyuki Sano; Ichiro Sori; Kozo Shinozaki; Hidekazu Oyamada; Shigeru Ikeda

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
221 KB
Volume
27
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied. The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF. The formation of 3-benzyltyrosine from e-benzyl tyrosine in the total deprotection step by HF of protected peptides containing tyrosine is one of the most hazardous side reactions in peptide synthesis.' Recently "low HF" cleavage procedure was reported to be useful to suppress

📜 SIMILAR VOLUMES

A New Reagent for the Cleavage of NPS-Am
A New Reagent for the Cleavage of NPS-Amino Protecting Groups in Peptide Synthesis
✍ Marcel Juillerat; J. Pierre Bargetzi 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 German ⚖ 840 KB

## Abstract The value of several reagents capable of removing quantitatively the α‐amino protecting group of NPS‐aminoacyl‐ or peptidyl‐derivatives is assessed, by comparison with the reagents currently used, __i.e.__ hydrogen chloride, RS^–^‐nucleophiles or alkyl thioamides, especially with regard

ChemInform Abstract: Use of a Heck React
ChemInform Abstract: Use of a Heck Reaction for the Synthesis of a New α-Azido Phosphotyrosyl Mimetic Suitably Protected for Peptide Synthesis.
✍ Terrence R. Burke Jr.; Ding-Guo Liu; Yang Gao 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis of N-protected peptides by the
Synthesis of N-protected peptides by the o-nitrophenylsulfenyl group using o-nitrophenylsulfenyl N-carboxy α-amino acid anhydrides
✍ Ryoichi Katakai; Masanao Oya 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 482 KB 👁 1 views

## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i