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Synthesis of N-protected peptides by the o-nitrophenylsulfenyl group using o-nitrophenylsulfenyl N-carboxy α-amino acid anhydrides

✍ Scribed by Ryoichi Katakai; Masanao Oya

Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
482 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

N‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of o‐nitrophenylsulfenyl (Nps) N‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids in aqueous organic systems. An Nps hexapeptide ester was prepared by the fragment condensation of an Nps tripeptide with a tripeptide ester. It was demonstrated that the synthesis of unprotected peptides by the NCA method, followed by N‐protection by the Nps‐NCA, is a rapid and very useful method for preparing Nps peptides.

📜 SIMILAR VOLUMES

Peptide synthesis using o-nitrophenylsul
Peptide synthesis using o-nitrophenylsulfenyl N-carboxy α-amino acid anhydrides. Sequential oligopeptides having alternate γ-methyl L-glutamyl and L-phenylalanyl residues
✍ Ryoichi Katakai; Yohko Nakayama 📂 Article 📅 1976 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 494 KB

## Abstract A series of sequential oligopeptides having the sequence alternating γ‐methyl L‐glutamyl and L‐phenylalanyl residues have been successfully prepared by a rapid method involving the reaction of __o__‐nitrophenylsulfenyl __N__‐carboxy α‐amino acid anhydrides with amino acid and peptide es