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Methoxymethylation of thallous cyclopentadienide. Simplified preparation of a key intermediate for the synthesis of prostaglandins

โœ Scribed by Corey, Elias J.; Koelliker, Urs; Neuffer, Jorg


Book ID
126300193
Publisher
American Chemical Society
Year
1971
Tongue
English
Weight
287 KB
Volume
93
Category
Article
ISSN
0002-7863

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The iodo lactone I, which has been used as a key intermediate for the synthesis of the six natural primary prostaglandins, is readily available by a synthetic process in which the average yield per step is 95% (l-4). Although the A prostaglandins can be derived from the primary E prostaglandins by d

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