Methoxymethylation of thallous cyclopentadienide. Simplified preparation of a key intermediate for the synthesis of prostaglandins
โ Scribed by Corey, Elias J.; Koelliker, Urs; Neuffer, Jorg
- Book ID
- 126300193
- Publisher
- American Chemical Society
- Year
- 1971
- Tongue
- English
- Weight
- 287 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The iodo lactone I, which has been used as a key intermediate for the synthesis of the six natural primary prostaglandins, is readily available by a synthetic process in which the average yield per step is 95% (l-4). Although the A prostaglandins can be derived from the primary E prostaglandins by d
Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int