𝔖 Bobbio Scriptorium
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Methotrexate resistance by gene amplification

✍ Scribed by Shields, Robert

Book ID
109709576
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
270 KB
Volume
273
Category
Article
ISSN
0028-0836

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## Abstract Disruption of the DNA methylation landscape is one of the most common features of human tumors. However, genetic alterations of DNA methyltransferases (DNMTs) have not been described in carcinogenesis. Herein, we show that pancreatic and breast cancer cells undergo gene amplification of