Cell biology: Gene amplification and drug resistance
β Scribed by Fox, Margaret
- Book ID
- 109734219
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 260 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/307212a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Gene amplification and copy number changes play a pivotal role in malignant transformation and progression of human tumor cells by mediating the activation of genes and oncogenes, which are involved in many different cellular processes including development of drug resistance. Since dox
## Multidrug resistance (MDR) is developed in a population of somatic mammalian cells in vivo or in vitro when they are selected for resistance to each of a large group of drugs (colchicine, adriamycin, actinomycin D , etc.). It isproduced by the amplification of some unknown gene@) whose praduct(s)
## Abstract Disruption of the DNA methylation landscape is one of the most common features of human tumors. However, genetic alterations of DNA methyltransferases (DNMTs) have not been described in carcinogenesis. Herein, we show that pancreatic and breast cancer cells undergo gene amplification of