Gene Amplification and Drug Resistance
โ Scribed by Schimke, Robert T.
- Book ID
- 109994461
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 770 KB
- Volume
- 243
- Category
- Article
- ISSN
- 0036-8733
No coin nor oath required. For personal study only.
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Unequal sister chromatid exchange has been proposed as one of several possible mechanisms for gene amplification resulting in tandemly repeated sequences on chromosomes. Two requirements for testing this hypothesis are analytical observations and a mathematical model. Recently observations were repo
## Abstract Gene amplification and copy number changes play a pivotal role in malignant transformation and progression of human tumor cells by mediating the activation of genes and oncogenes, which are involved in many different cellular processes including development of drug resistance. Since dox