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Metabolism of Leukotriene B4 (LTB4) and 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid (12-HETE) in Human Keratinocytes

✍ Scribed by PAT WHEELAN; JEFFREY B. TRAVERS; JOSEPH G. MORELLI; ROBERT C. MURPHY


Book ID
119871140
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
506 KB
Volume
744
Category
Article
ISSN
0890-6564

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12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetra
✍ Shoko Ueki; Junichi Takagi; Yuichi Kobayashi; Fumie Sato; Yuji Saito πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 150 KB

We report here that the 12-lipoxygenase metabolite of arachidonic acid, 12hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE), stimulates cAMP production in human fibroblasts among various cultured cell lines tested. Although 12-HETE seemed to stimulate the phospholipase C (PLC)-protein kinase