Metabolic formation and synthesis of 1-(3-chlorophenyl)-2-(4-hydroxyphenyl)-1-methyl-2-(2-pyridine)ethanol. A potential hypocholesteremic agent
✍ Scribed by Sinsheimer, J. E.; Van den Eeckhout, E.; Hewitt, L. E.; Kido, Y.; Wade, D. R.; Hansen, D. W.; Drach, J. C.; Burckhalter, J. H.
- Book ID
- 126875535
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 582 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2623
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## Abstract 2‐(2‐Pyridine)‐1‐(3‐chlorophenyl)‐2‐phenyl‐1‐methylethanol (I), containing tritium uniformly distributed in the 2‐phenyl ring, was synthesized in two steps with tritiated benzene as the labelled starting material. An improved procedure was employed for the coupling of m‐chloroacetophen
The methanesulfonates of ( \(\alpha\)-(4-chlorophenyl)- \(\alpha\)-[1-(2-chlorophenyl)ethenyl]-1 \(H\)-1,2,4-triazole-1-ethanol and \(\alpha\)-[1-(2-chlorophenyl)ethenyl]- \(\alpha\)-(2,4-difluorophenyl)-1H-1,2,4-triazole-1-ethanol (1a,b) are orally effective \(\alpha\) styryl carbinol derivatives d