Inhibition of hepatic lipid biosynthesis by 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine) ethanol, a hypocholesterolemic agent
β Scribed by Kozo Ishidate; John C. Drach; Joseph E. Sinsheimer; Joseph H. Burckhalter
- Book ID
- 115775411
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 386 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0006-2952
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## Abstract 2β(2βPyridine)β1β(3βchlorophenyl)β2βphenylβ1βmethylethanol (I), containing tritium uniformly distributed in the 2βphenyl ring, was synthesized in two steps with tritiated benzene as the labelled starting material. An improved procedure was employed for the coupling of mβchloroacetophen
1,2,3,6-Tetrahydr0-4-[U-1~C]phenylpyridine (12) was synthesized and coupled to (R)-3-phenyl-3-cyclohexene-1-carboxylic acid to make the titled compound 2 in 21% overall yield. Purification considerations were an important factor in the choice of a reaction sequence to 2, and successful synthesis was